Hydroxyapatite - Hyaluronic acid scaffold production using solvent extraction method

Document Type : Research Paper

Authors

1 دانشگاه صنعتی شاهرود، دانشکده مهندسی شیمی و مواد

2 School of Chemistry and Materials Enginnering, Shahrood University of Technology

Abstract

The purpose of this study was to evaluate the simultaneous effect of Hyaluronic acid (HA) - Polyvinyl alcohol (PVA) - Gelatin (Gel), and nano Hydroxyapatite (nHAp), which is mineral in bone. In this study, for the first time, bone scaffold of nHAp and bioresorbable polymers (HA, PVA, and Gel) was prepared by solvent evaporation method. The composite specimens were prepared using nHAp-PVA, nHAp-PVA-Gel and nHAp-PVA-HA, four-component nHAp-PVA-HA-Gel, using a simple liquidation process. Phase and chemical analysis were investigated by FTIR and XRD tests. The distribution and porosity size and their relationship to each other as well as the roughness of porosity were studied using scanning electron microscopy. The compressive strength test was also performed on tablets prepared from this composite. The FTIR test did not indicate the formation of a new chemical compound. The compressive strength indicated that the four minor sample had the highest numerical value. Investigating the SEM analysis of the formation of scaffolds for a four-part sample, which shows porosity percentage, porosity size and bonding, suggest the suitability of this sample for tissue engineering applications. The analysis of the XRD is an amorphous specimen and, given the similarity of the natural bone XRD diagram, this composite can be used as a bone filler.

Keywords

References

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History

  • Receive Date: 30 May 2019
  • Revise Date: 16 June 2019
  • Accept Date: 09 June 2019

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